Aging’s Scientific Integrity Process

The open-access journal Aging recently launched a new webpage showcasing the full Aging Scientific Integrity Process.

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BUFFALO, NY-Novembe8, 2022 – Scientific integrity is a crucial component of scholarly publishing for any credible journal. Peer-reviewed, open-access journal Aging (listed as “Aging (Albany NY)” by Medline/PubMed and “Aging-US” by Web of Science) has recently presented its Scientific Integrity process.

Launched in 2009, Aging is an open-access biomedical journal dedicated to publishing high-quality, aging-focused research. Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. 

Aging has a scientific integrity process to ensure that publications meet a number of scrupulous criteria for authenticity and integrity. Each published paper is thoroughly analyzed by diligent reviewers and services, including multiple in-house developed image forensics softwares. A growing industry of digital technologies, tools and ideas are constantly being added to Aging’s scientific integrity toolbox. 

Aging’s Scientific Integrity process is built upon six critical components:

  1. Easily Accessible Ethics Statements
  2. Devotion to Industry Standards for Scientific Publishing
  3. Rigorous and Insightful Peer Review
  4. Detection and Zero-Tolerance of Plagiarism
  5. Leading-Edge Image Forensics
  6. Post-Publication Investigations (if needed)

You can read about each of these components in greater detail on Aging’s new Scientific Integrity webpage

The new webpage also depicts publishing statistics in a detailed graph (below)—showcasing a visual representation of the number of post-publication corrections and retractions by Aging compared to the industry average, between 2010 and 2022. As of September 2022, Aging’s average rate of corrections/retractions since 2009 is a low 2.33%. The industry average correction/retraction rate is 3.80%. 

Image forensics corrections/retractions (published & pending) as a percent of IF-eligible articles in Aging, 2009-2022

Aging’s highly-effective scientific integrity process allows researchers to read, share and cite Aging papers with confidence.

Click here for Aging’s full Scientific Integrity Process.

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Aging’s Top 10 Most-Viewed Papers in 2021

Aging's Top 10 papers of 2021

Read the 10 most-viewed papers on of 2021.

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#10: Iron: an underrated factor in aging

Author: Dennis Mangan

Institution: MTOR LLC

Quote: “Blocking iron absorption through drugs or natural products extends lifespan. Many life-extending interventions, such as rapamycin, calorie restriction, and old plasma dilution can be explained by the effects they have on iron absorption, excretion, and metabolism.”

#9: Reversal of cognitive decline: A novel therapeutic program

Author: Dale E. Bredesen

Institutions: University of California Los Angeles and Buck Institute for Research on Aging

Quote: “This report describes a novel, comprehensive, and personalized therapeutic program that is based on the underlying pathogenesis of Alzheimer’s disease, and which involves multiple modalities designed to achieve metabolic enhancement for neurodegeneration (MEND).”

#8: Shorter telomere lengths in patients with severe COVID-19 disease

Authors: Raul Sanchez-Vazquez, Ana Guío-Carrión, Antonio Zapatero-Gaviria, Paula Martínez, and Maria A. Blasco

Institutions: Spanish National Cancer Research Center – CNIO and Field Hospital COVID-19, IFEMA

Quote: “The incidence of severe manifestations of COVID-19 increases with age with older patients showing the highest mortality, suggesting that molecular pathways underlying aging contribute to the severity of COVID-19. One mechanism of aging is the progressive shortening of telomeres, which are protective structures at chromosome ends.”

#7: Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients

Authors: Ronit Shapira, Amos Gdalyahu, Irit Gottfried, Efrat Sasson, Amir Hadanny, Shai Efrati, Pablo Blinder, and Uri Ashery 

Institutions: Tel Aviv University and Assaf Harofeh Medical Center

Quote: “Hyperbaric oxygen therapy (HBOT) is in clinical use for a wide range of medical conditions. In the current study, we exposed 5XFAD mice, a well-studied AD model that presents impaired cognitive abilities, to HBOT and then investigated the therapeutical effects using two-photon live animal imaging, behavioral tasks, and biochemical and histological analysis.”

#6: Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19?

Authors: Anna Kovalchuk, Bo Wang, Dongping Li, Rocio Rodriguez-Juarez, Slava Ilnytskyy, Igor Kovalchuk, and Olga Kovalchuk

Institutions: Pathway Research Inc.University of Calgary and University of Lethbridge

Quote: “Cannabis sativa has been proposed to modulate gene expression and inflammation and is under investigation for several potential therapeutic applications against autoinflammatory diseases and cancer. Here, we hypothesized that the extracts of novel C. sativa cultivars may be used to downregulate the expression of pro-inflammatory cytokines and pathways involved in inflammation and fibrosis.”

#5: Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States

Authors: Rebecca Robbins, Stuart F. Quan, Matthew D. Weaver, Gregory Bormes, Laura K. Barger, and Charles A. Czeisler

Institutions: Brigham and Women’s HospitalHarvard Medical School and Boston College

Quote: “Sleep disturbance and deficiency are common among older adults and have been linked with dementia and all-cause mortality. Using nationally representative data, we examine the relationship between sleep disturbance and deficiency and their risk for incident dementia and all-cause mortality among older adults.”

#4: Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test

Authors: Oleksandr Demidenko, Diogo Barardo, Valery Budovskii, Robb Finnemore, Francis R. Palmer III, Brian K. Kennedy, and Yelena V. Budovskaya

Institutions: TruMe Inc.National University SingaporePonce de Leon HealthNational University Health System Singapore, and Singapore Institute for Clinical Sciences, A*STAR

Quote: “Instead, aging biomarkers, such as DNA methylation (DNAm) clocks, have been developed to monitor biological age. Herein we report a retrospective analysis of DNA methylation age in 42 individuals taking Rejuvant®, an alpha-ketoglutarate based formulation, for an average period of 7 months.”

#3: Aging and rejuvenation – a modular epigenome model

Authors: Priscila Chiavellini, Martina Canatelli-Mallat, Marianne Lehmann, Maria D. Gallardo, Claudia B. Herenu, Jose L. Cordeiro, James Clement, and Rodolfo G. Goya

Institutions: National University of La PlataNational University of CordobaWorld Academy of Art and Science (WAAS), and Betterhumans Inc.

Quote: “The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging.”

#2: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Authors: Kara N. Fitzgerald, Romilly Hodges, Douglas Hanes, Emily Stack, David Cheishvili, Moshe Szyf, Janine Henkel, Melissa W. Twedt, Despina Giannopoulou, Josette Herdell, Sally Logan, and Ryan Bradley

Institutions: Institute for Functional MedicineAmerican Nutrition AssociationNational University of Natural MedicineAriel UniversityMcGill University, and University of California San Diego

Quote: “Manipulations to slow biological aging and extend healthspan are of interest given the societal and healthcare costs of our aging population. Herein we report on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50-72.”

#1: Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial

Authors: Yafit Hachmo, Amir Hadanny, Ramzia Abu Hamed, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Bechor, and Shai Efrati

Institutions: Shamir Medical CenterTel Aviv University and Bar Ilan University

Quote: “At the cellular level, two key hallmarks of the aging process include telomere length (TL) shortening and cellular senescence. Repeated intermittent hyperoxic exposures, using certain hyperbaric oxygen therapy (HBOT) protocols, can induce regenerative effects which normally occur during hypoxia. The aim of the current study was to evaluate whether HBOT affects TL and senescent cell concentrations in a normal, non-pathological, aging adult population.”

Click here to read the latest papers published by Aging.

AGING (AGING-US) VIDEOS: YouTube | LabTube |

Aging (Aging-US) is an open-access journal that publishes research papers bi-monthly in all fields of aging research. These papers are available to read at no cost to readers on Open-access journals offer information that has the potential to benefit our societies from the inside out and may be shared with friends, neighbors, colleagues, and other researchers, far and wide.

For media inquiries, please contact [email protected].

Aging Testimonial: Dr. Kara Fitzgerald

Below is a transcript of the testimonial by Dr. Kara Fitzgerald, from the Institute for Functional Medicine in Federal Way, Washington, about her experience publishing the paper, “Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial,” with Aging.

Researchers explain their studies that were published in Aging
Researchers explain their studies that were published in Aging
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Dr. Kara Fitzgerald:

I am thrilled with our study being accepted into the journal Aging. I think it’s the perfect home for it.

The process of submitting and our peer review journey was actually, it was actually a lot of fun! I found our peer reviewers, they really move our study forward and help us to articulate our findings and inquisitive, appreciative of what we’ve done. And so that whole piece of it was good.

Dr. David Sinclair actually suggested that Aging would be the right home for us and I couldn’t agree more.

What else? It’s open access. I think open access is essential. Having our study behind a paywall and inaccessible to other scientists and just the community who might be interested in the longevity research that’s happening, particularly this, which is a diet and lifestyle program so, it’s something that people could actually do if they wanted to. We want that available. So I’m all for open access.

I enjoyed working with Aging. I thought that they were good across the board. And I just appreciate David’s recommendation that we go here.

Click here to read the full study published by Aging.

Click the links below for more information on corresponding author, Dr. Kara Fitzgerald:
Biological Aging Summary | Instagram | Facebook | Twitter | General Site | Younger You Program


Aging is an open-access journal that publishes research papers monthly in all fields of aging research and other topics. These papers are available to read at no cost to readers on Open-access journals offer information that has the potential to benefit our societies from the inside out and may be shared with friends, neighbors, colleagues, and other researchers, far and wide.

For media inquiries, please contact [email protected].

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